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Genetic and pharmacologic NNMT suppression reduces adiposity and improves metabolic readouts in preclinical models, with supportive cellular data showing increases in NAD and SAM and suppression of lipogenesis

By reducing NNMT catalytic activity, the compound allows researchers to evaluate how limiting nicotinamide methylation influences: In vitro and in vivo experimental models (non-clinical, non-human) have demonstrated that NNMT suppression leads to measurable changes in cellular energy markers and adipocyte behavior

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