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Phua et al., 2020
MOTS-c is also the better starting point for patients who want to support physical performance and recovery, because it acts as what researchers describe as an exercise mimetic, activating some of the same cellular pathways that exercise triggers
These inflammatory factors promote the release of matrix metalloproteinase-9, which in turn degrades the tight junction protein Claudin-5, ultimately disrupting the integrity of the BBB, and leading to the phenomenon of "leaky brain" [93]
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