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Activated Protein C (APC), which cleaves protease-activated receptor 1 in brain endothelium and targets Rac1 GTPase, strengthens the BBB via the -arrestin-2-dependent biased signaling pathway [285]
However, it requires conversion in the liver to methylcobalamin and adenosylcobalamin before it can be used in enzymatic reactions
Another important gastric secreted protein is pepsinogen, which is cleaved by the HCl into pepsin, an enzyme that assists in the digestion of dietary proteins
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