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After 3 d, TGR dsRNA-treated parasites had darker bodies with internal vacuoles and did not move, while all irrelevant dsRNA-treated parasites showed contractile movement and had clear bodies (Figures 8 and Figure S2)
In our study, FA 250mg/kg at the concentration of 12.5mg/ml was selected to induce AKI due to the higher concentration of FA (25 or 50mg/ml) could induce the death of mice
Accordingly, mice with liver-specific IGF-I deficiency, instead of displaying decreased hepatic growth, showed disproportionally large livers, likely due to direct stimulation by an unsuppressed GH secretion[47, 93]
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