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Senescent tumour cells, though growth-arrested, remain metabolically active and can persist in the tumour microenvironment, promoting inflammation, tumour progression, and eventual relapse
This can lead to severe discomfort and cause food to stay in the stomach for extended periods, causing bacterial overgrowth, malnutrition, and other uncomfortable gastrointestinal symptoms
In addition, semaglutide, liraglutide, and tirzepatide are GLP-1R agonists that are FDA-approved [69]
Liu YL, Connoley IP, Heal DJ, Stock MJ (2004)
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