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Pathway level effects reported are changes in kinase mediated signal transduction activity, transcriptional activity related to matrix deposition and control of factors associated with cellular migration and adhesion

Before the approval of PT-141, there were limited treatment options for HSDD

The six IGFBPs serve as carrier proteins that bind approximately 98% of all circulating native IGF-1, with binding affinity equal to or greater than that of the IGF-1 receptor itself meaning the vast majority of native IGF-1 is sequestered before reaching its receptor

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