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Another component of aging is the decline in the immune system, known as immunosenescence.[ref][ref] Melatonins role in longevity is thought to be two-part: antioxidant activity and immune system stimulation

Apoptosis inhibitor of macrophage (AIM), also called CD5 antigen-like (CD5L), is a 36 kDa soluble protein that belongs to the SRCR superfamily Group B with three head-to-tail linked SRCR domains, mainly expressed by tissue-resident macrophages in the liver as well as lymphoid and inflamed tissues 3,4