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the skin disease is clinically significant and either inadequately controlled or imposing a high burden of flares, procedures, pain, or quality-of-life impairment

Guidelines and Recommendations : Professional organizations, such as the American Diabetes Association (ADA) and the Endocrine Society, periodically release guidelines that include considerations for the use of GLP-1 receptor agonists like semaglutide, taking into account their impact on gallbladder health among other safety and efficacy factors

This video is about how we discovered these world changing drugs

[1] These medications work by mimicking the action of naturally occurring GLP-1, an incretin hormone that stimulates insulin secretion in response to food intake, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways