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(January 2026)
Conclusion and Future perspectives Since the first description of LHON in 1871, 19 and the subsequent discoveries of the roles of mtDNA and nDNA in mitochondrial genetic disorders in 1988 32,33 and 1995, 37 the field has transitioned from the pre-molecular era to the molecular era
In a research context, the main limitations are the gap between animal and human data, stability sensitivity requiring proper storage, and the risk of compromised results if purity is not independently verified
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