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Uno studio clinico in doppio cieco condotto su donne affette da PCOS* ha mostrato che il gruppo che assumeva L-carnitina aveva un ciclo mestruale pi regolare rispetto al gruppo placebo, con un tasso di gravidanza pi elevato
However, it should be noted as mentioned previously, in conditions where it does not increase glucose oxidation, carnitine supplementation worsens both injury and recovery of contractile function after transient ischemia in the perfused rat heart [122]
However, expanded access may also create new operational challenges
Broad interest is now focused on the biguanide metformin 37, 38 (see review in the same issue of this topical issue) as well as IR and IGF-1R inhibitors
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