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The mechanisms behind this hypoperfusion may involve astrocyte energy metabolism compromise due to lacking 2-adrenergic receptors, and increased vasoconstriction from elevated ET-1 [273,274,275]

Glutathione production by our bodies naturally decreases with age, but can also be impacted by diet, physical activity, alcohol intake, infections, stress, certain medications, and chronic illness

Document any changes in the relevant research endpoints (recovery time, inflammation markers, dermal response) and adjust within the protocols design parameters