semaglutide being discontinued 🔥 A new study found that prolonged treatment with the GLP-1 receptor agonist doesn't just reduce food intake—it reshapes how animals eat and how their metabolism adapts across distinct stages of What happens when patients stop

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On the latter, studies conducted using site-specific brain micro-injections and single-photon emission computed tomography documented a novel regulatory role of the hypothalamic supramammillary nucleus in the regulation of food intake and reward, posing this brain area as one of the main targets of the GLP1/E conjugate, along with the lateral hypothalamus and the nucleus of the solitary tract, whose activation may be responsible for the anorectic, weight-lowering and reward reducing effects of this multi-agonist 51

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doi: 10.1016/j.lfs.2019.01.048 33 XueJLiXLiuPLiKShaLYangXet al