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Rather than replicating the full TB4 protein, TB-500 is based on the short actin-binding fragment responsible for much of TB4s cell-migration activity, which makes it more practical to synthesise for research use
The investigators suggested that the phenomenon might occur due to the competition between insulin and A for the degradative pathway by insulin-degrading enzyme (IDE), an enzyme involved in the clearance of extracellular A from the brain (Shiiki et al., 2004)
10.1016/j.jmb.2020.05.020 107 SeneffS.KyriakopoulosA
As you can imagine, this serves as an intermediate pathway between oral supplements and full on IV infusion
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