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Gastrointestinal Fluid Loss The most common GLP-1 side effects are gastrointestinal: Nausea: 44% of Wegovy users, 56% of Zepbound users Vomiting: Increases relative risk 2.90-2.95x vs placebo Diarrhea: Common across all GLP-1 medications Each episode of vomiting or diarrhea depletes 100-500mg of sodium plus potassium, magnesium, and calcium

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