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The substitution at position 2 is the functionally important one: it blocks cleavage by dipeptidyl peptidase-4, the protease that degrades native GRF within minutes

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M., Saha, K., & Steinberg, W

Keep these tips in mind when buying products and building a skin care routine: Use a low pH cleanser to speed exfoliation The best cleansers for melasma are discussed here Use skin-lightening ingredients that will not irritate your skin type Use moisturizers with unsaturated fatty acids that inhibit tyrosinase Use moisturizers that help tyrosinase inhibitors absorb into the skin Combine the tyrosinase inhibitors with antioxidants and soothing ingredients to reduce inflammation because inflammation causes pigmentation Combine with PAR-2 inhibitors that block the transfer of melanin into skin cells Wear a tinted mineral (physical) SPF since iron oxides protect the skin from blue light Combine with microdermabrasion or chemical peels Consider a supplement or vitamin such as pycnogenol, melatonin, or polypodium leucotomos to block skin pigment production Change your lifestyle to get rid of melasma There is a prescription pill used to treat melasma - it is not FDA approved but it is often used Best Moisturizer to Use with Tyrosinase Inhibitors Look for moisturizers with unsaturated fatty acids