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In a complementary approach, exenatide-functionalized DFO NPs effectively chelated excess iron and preserved dopaminergic neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model [207]
Regulatory authorities such as the European Medicines Agency recommend limiting use to short durations (typically 24 weeks) and emphasize careful monitoring and tapering strategies
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