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IL-1-induced chondrocytes were incubated with 10 ascending doses (6.6, 13.3, 26.6, 53.1, 106.3, 212.5, 425, 850 nM, 1.7 and 3.4 M) of liraglutide for 24 h to determine the half maximal inhibitory concentration (IC 50 ) of the inflammatory mediators NO, PGE 2 , and IL-6 (Fig

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Resistance training and sufficient protein intake are especially important when taking GLP-1s, because you can lose lean muscle along with unwanted body fat