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Statistical analysis was performed by t -test (unpaired or paired, as indicated), one-way analysis of variance (ANOVA), two-way ANOVA (time treatment or genotype treatment) with post hoc comparisons (where appropriate, as indicated in the figure legends)
Dev Neurosci 38(4):264276
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As a small-molecule drug, orforglipron relies on: Multi-step organic synthesis High-purity pharmaceutical intermediates Strict impurity and batch-to-batch consistency control Scalable, GMP-compliant manufacturing processes Unlike peptide-based injectables, oral GLP-1 candidates place greater emphasis on chemical process robustness, particularly at the intermediate stage
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