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Geneva: World Health Organization (2023)

Low B12 doesnt directly cause weight gain, but chronic fatigue and slow metabolism from a deficiency may lead to reduced activity levels, contributing to weight gain over time

Under mild or transient heat stress, HSF1-mediated HSP induction can facilitate protein refolding, prevent protein aggregation, preserve mitochondrial function, and promote germ-cell survival

This interaction activates the Akt/mTOR pathway , which is responsible for: Stimulating muscle protein synthesis Promoting cell proliferation and differentiation Enhancing collagen and connective tissue formation Supporting cellular repair and regeneration A review 3 explains that this biochemical process makes IGF-1 LR3 a promising tool for maintaining or regaining muscle mass, particularly during recovery or rehabilitation periods