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Indeed, when hepatic PGC-1 levels are high, mice liver appeared intensely affected by oxidative stress, as depicted by extensive accumulation of ROS byproducts (8-Oxo-DG, NITT and HNE), that is suggestive of the prelude to hepatic necrosis and death

As of mid-2026 it is not approved as a standalone drug for obesity, type 2 diabetes, or any other indication by the FDA, the EMA, or comparable regulators

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