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This triggers a dual effect on: Glucose-Dependent Secretion: The rise in cAMP activates Protein Kinase A (PKA) and Epac (Exchange Protein directly activated by cAMP)

Existing Licensed Alternatives Available on the NHS Licensed weight management medicines currently available in the UK include semaglutide (Wegovy), tirzepatide (Mounjaro), orlistat, liraglutide (Saxenda), and naltrexone/bupropion (Mysimba), subject to eligibility criteria

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