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Beyond the intrinsic properties of the photosensitizer, the ROS generation and ICD-inducing effects can be severely limited by the constraints of hypoxia and insufficient tumor penetration in the TME (54)
It is interesting to note that other post-acute infection syndromes (PAIS) and some neuropsychiatric diseases such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), depression (especially the atypical/immunometabolic subtype (IMD) [86]) and others also have fatigue as a leading clinical symptom, which may serve as a model for investigating the mechanisms of fatigue and drawing conclusions regarding therapeutic options in long COVID
furthermore, the in vitro migration and rate of spreading of tendon fibroblasts increased in a dose-dependent manner, which was attributed to the activation of the FAK-paxillin pathway
Unlike broad categories of research materials, specialized compounds often become the focus of targeted investigative programs
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