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In db/db mice, CK treatment increases secondary BAs, such as lithocholic acid (LCA) and deoxycholic acid (DCA) through changes in the gut microbiota, especially the Ruminococcaceae family, and up-regulation of cytochrome P450 family 7 subfamily B member 1 ( Cyp7b1 ) and cytochrome P450 family 27 subfamily A member 1 ( Cyp27a1 ) and down-regulation of cytochrome P450 family 8 subfamily B member 1 ( Cyp8b1 ), which changes BA biosynthesis from the classical pathway to the alternative pathway

For people with a history of restrictive eating disorders, this can be a double-edged sword

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The American Heart Association and other experts recommend a diet that emphasizes 51,52 : Fruits and vegetables Whole grains Nuts and legumes Fish and skinless poultry, with limited amounts of red meat Non-tropical vegetable oils, such as olive, sunflower, safflower, canola, and other oils low in saturated fat