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The investigators examined 15 patients with mid-stage PD, who gave themselves a single dose of GSH nasal spray while inside the MRI scanner, and whose GSH levels in the CNS were measured before spray administration and over the hour that followed administration

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The combination of phentermine, a psychostimulant, and topiramate, a carbonic anhydrase inhibitor, has been associated with increased heart rate (Alfaris 2015)