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These include pancreatitis (rare but reported in clinical trials and post-marketing surveillance), gallbladder disease, and acute kidney injury (particularly in the setting of severe dehydration from gastrointestinal effects)
For example, gut microbiota-derived indole-3-acetic acid (3-IAA), a tryptophan metabolite, accumulates in the TME and is oxidized by neutrophil myeloperoxidase (MPO), generating a burst of ROS
Never modify RA treatment without consulting your rheumatologist
Recognising the signs is important, and one symptom may present itself when you go to the toilet
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