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While native GLP-1 contributes to normal glucose regulation, semaglutide produces receptor activation at levels that exceed endogenous postprandial GLP-1 concentrations, generating clinically significant HbA1c reduction and weight loss

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doi:10.1007/s00125-003-1103-y 316

Patients with kidney stones, electrolyte imbalances, or certain medical conditions should avoid high doses of intravenous vitamin supplementation