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Empagliflozin mitigates cardiac hypertrophy through cardiac RSK/NHE-1 inhibition
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Over the next decade, they isolated the active compound responsible for this effect, sequenced it, synthesized it, and in 1977 published their findings
Within the framework of clinical trial design, predictive modeling based on imaging, body fluid biomarkers, genetics, and digital signals can enhance participant selection, identify fast progressors or treatment-responsive subgroups, and enable real-time adaptive modifications to trial parameters
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