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The peptide appears to promote tenocyte proliferation and enhance extracellular matrix synthesis, leading to improved biomechanical properties of repaired tissues

cDNA microarray analysis of rat Achilles tendon fibroblasts identified the growth hormone receptor as one of the most abundantly up-regulated genes following exposure to the peptide, with concentration- and time-dependent increases confirmed at both mRNA and protein level, and downstream Janus kinase 2 activation observed on subsequent growth hormone stimulation [3]

The initial mechanical damage, the primary injury, is followed by hours, days, and weeks of secondary injury processes that often cause more functional loss than the impact itself

For some reason, and I can find no scientific basis for this, that recommendation was changed in 1974 to an injection every two months and then in 1984 to every three months