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Our improved understanding of the complex biological regulation of appetite, metabolism and body weight, involving co-ordinated responses between peripheral tissues and central appetite-regulating centres, has resulted in the availability of nine Food and Drug Administration (FDA) (liraglutide, semaglutide, tirzepatide, orlistat, phentermine, phentermine/topiramate, bupropion-naltrexone, setmelanotide, and metreleptin), and seven European Medicine Agency (EMA) (excluding phentermine and phentermine/topiramate), approved AOMs

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Broader immune-mediated reactions may develop weeks later or after dose escalation