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By screening appropriately and choosing compounds based on both mechanism and medical history, we can maximize regenerative benefits while minimizing oncologic risk
10.1016/j.biopha.2023.115607 92 ShiB.CuiQ.FengZ.LiJ
f - j , Cumulative food intake by virus at 1,2,4,6 and 21 hr in eGFP and DTA mice administered semaglutide (60 g/kg, s.c.), 2-way mixed-model ANOVA: ( f ) Drug F(1,13)=1.965, p = 0.184
To improve the selectivity, in this work, we design and synthesize a malononitrile-functionalized TPE derivative, TPE-DCV, which can undergo addition reaction with thiol group to the alkene bond, leading to the change in its fluorescence in the system (Figure 1)
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