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61 ECC5004 The preliminary results of the investigational agent ECC5004 phase 1 trial in non-human primates revealed a reduction in HbA1c levels, accompanied by weight loss and a decreased risk of adverse cardiovascular events, achieved through the mimicry of the hormone GLP-1

Similarly, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD, increased BBB permeability to Evans blue and FITC-albumin was observed in the striatum but not in the hippocampus [114], indicating region-specific BBB impairment in PD pathophysiology

doi:10.1016/j.dmpk.2016.08.005 Nalecz KA, Miecz D, Berezowski V, Cecchelli R (2004) Carnitine: transport and physiological functions in the brain