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SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103
Moreover, supplementation with Lactobacillus plantarum (DP189) and GOS restored gut microbial composition, improved gut and BBB integrity, reduced cortical inflammation and elevated acetylcholinesterase activity, reversing anxiety and depression-like behaviors in mice (Wang J
Transient constipation or altered bowel habits
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