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Early research shows retatrutide results in significant weight loss in people with overweight and obesity
Until today, the longest observational period for semaglutide treatment for obesity is 2 years (STEP 5)
Genetic variation in peptide receptorsspecifically the GLP-1 receptor (GLP1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR)influences how your body responds to semaglutide, tirzepatide, and other compounds
No trial has directly compared the two, so this is an indirect comparison across trials rather than a measured difference
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