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Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: possible implications for susceptibility to amodiaquine-induced liver toxicity
By acting as a carrier for TPL, liposomes further enhance its pharmacokinetics compared to free TPL, extending the drugs in vivo duration, significantly reducing toxicity, and markedly improving therapeutic effects through a controlled release mechanism (Ren et al., 2021)
We report that NAC effectively prevents the harmful effects of adolescent THC exposure, highlighting its potential as a therapeutic intervention for treating long-term neuropsychiatric consequences of chronic developmental cannabis exposure
