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It is commonly used off-label in oral form to support hair health, and is believed to increase blood flow to hair follicles and extend the hair growth (anagen) phase
The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking
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MOTS-c influences mitochondrial signaling pathways that interact with the bodys fasted-state metabolic processes
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