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Severe Depression or Suicidal Ideation : Given reports linking GLP-1 RAs to increased risks of depression and suicidal behaviour, patients with these conditions require meticulous evaluation

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GLP-1 RAs bind to the G protein-coupled GLP-1 receptor, whose activation results in insulin synthesis and release by pancreatic beta cells

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One thing to keep in mind about GLP-1s is that once you stop taking them, weight regain is common if you don't have a sustainable plan in place

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