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More recent investigations evidenced how women working whole NS exhibit suppressed estradiol levels compared to DS workers, coinciding with disrupted sleep and melatonin rhythms, while half-NS did not significantly affect estradiol synthesis 259

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Although they are not involved in protein coding, the acquisition or loss of introns and the insertion position of introns relative to protein sequences are generally considered to be key clues to understanding the evolutionary diversity of gene families (Rogozin et al., 2000)