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Anand I, Chandrashekhan Y, De Giuli F, et al
If the Phase 3 trials (TRIUMPH series) read out as expected, MHRA approval is plausible in late 2026 or 2027
398 Furthermore, opioid receptors can stimulate the production of high mobility group box 1 (HMGB1), 399 an endogenous TLR4 agonist, facilitating intercellular communication (neuron-to-glia or glia-to-neuron)
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