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The one-carbon metabolic pathway is tightly regulated by intracellular levels of metabolites and cofactors, such as high intracellular SAM levels that activate CBS and inhibit MTHFR, thus shifting hcy levels from transmethylation toward transsulfuration reactions (Finkelstein, 2007)

Tirzepatide is administered as a once-weekly subcutaneous injection, with doses ranging from 2.5 mg to 15 mg depending on the indication and individual patient response