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In: Erdman JWJ, Macdonald IA, Zeisel SH, eds
It was used clinically in over 35 countries before the FDAs Category 2 restriction
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These neurons may be associated with anorexigenic POMC neurons and/or orexigenic AgRP neurons (24), or they may be associated with the brain, such as non-POMC anorexigenic neurons in the ARN, which have glutamatergic connections with the paraventricular nucleus of the hypothalamus (45)
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