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The finding shifted understanding of how mitochondria communicate beyond energy production, signaling through circulating peptides that reach distant tissues
Proper storage and handling ensures reproducible results across multiple experiments and research teams
Intranasal delivery offers a potential advantage: absorption through the olfactory and nasal mucosal pathways provides a more direct CNS route that partially bypasses the plasma degradation problem
What is documented is the outcome: a research protocol that treats 4.5 mg as the target is going past the dose the sponsor advanced after seeing the complete phase 2 dataset
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