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That level of weight loss was seen at the highest approved dose of semaglutide (2.4 mg) , which most people dont reach until several months into treatment due to gradual dose increases
Nature 619 , 475486 (2023)
Researchers should account for this accumulation period when designing study timelines
When exposed to endotoxin (LPS), IL-1, or IL-6, these cells rapidly increase GLP-1 secretion in both mice and humans, highlighting GLP-1 as a key communicator between the gut, immune system, and systemic inflammation
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