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Metformin HCl extended-release Following a single oral dose of 1,000 mg (2 500 mg tablets) metformin HCl extended-release after a meal, the time to reach maximum plasma metformin concentration (Tmax) is achieved at approximately 7 to 8 hours

J Biol Chem 1999, 274: 1414714156

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549 Therefore, the lactate/pyruvate ratio offers excellent diagnostic accuracy for distinguishing pyruvate dehydrogenase deficiency from other mitochondrial diseases

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