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The BMAL1 knockout mouse (BMAL1/) model was used to explore the effects of circadian clock dysfunction on the GH circulating levels and downstream pathways (Steyn et al., 2011), the GH secretion profile in male mice is characterized by a high-amplitude pulse pattern for less than 30 min every 33.5 h with some variability
3ad and Supplementary Fig
GDF-11 neutralisation may accelerate cardiac ageing in extended exposure studies monitoring required)
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