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the lifespan was significantly prolonged by counteracting oxidative stress, possibly through the epigenetic downregulation of histone H3 acetylation, thereby suppressing oxidative damage and necrosis
It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number
Yi-Jiang, X
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma
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