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This inactivation disrupts key enzymatic reactions, including the conversion of methylmalonyl-CoA to succinyl-CoA by methylmalonyl-CoA mutase and the synthesis of methionine from homocysteine (Hcy) by methionine synthase (Figure 2)

JAMA Network Open

Approval Based on Comprehensive Data: Oral semaglutides approval is based on comprehensive data from clinical trials, laboratory studies, and post-market reviews, ensuring it meets FDA standards for safety and efficacy for weight loss

Dose timing during pregnancy concerns Tirzepatide is not approved for use during pregnancy, and it should be discontinued if pregnancy occurs or is planned