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63 Albiglutide was approved for marketing in the European Union in March 2014 and in the United States in April 2014

GSH can oxidize after cells or tissues are collected, which can make GSH look lower and GSSG look higher than they were in the original sample

The following stepwise schedule mirrors the inverse of the titration ladder: | Week | Taper Step | Notes | |---|---|---| | Week 1 to 2 | Reduce from 12 mg to 8 mg | Monitor weight and GI symptoms | | Week 3 to 4 | Remain at 8 mg | Confirm tolerability of step-down | | Week 5 to 6 | Reduce from 8 mg to 4 mg | Expect modest appetite increase | | Week 7 to 8 | Remain at 4 mg | Reinforce dietary structure | | Week 9 to 10 | Reduce from 4 mg to 2 mg | Begin transition plan | | Week 11 to 12 | Final 2 mg injection, then stop | Schedule 4-week follow-up | Patients stopping from an 8 mg maintenance dose begin the taper at that level and follow the same 4 mg and 2 mg steps over 8 weeks

JP Patent 2, 002, 284, 664 Acknowledgments We are grateful to Dr