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In cohorts 1-4, participants were randomized in a 4:1 ratio to once-weekly subcutaneous injection of GZR4 (doses: 1 ,3 ,6 ,12 nmol/kg) or placebo, and cohort 5 administered with 0.4 U/kg of insulin degludec (IDeg) as a comparator

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These include antidepressants, steroids, and medications used to lower fever or treat diabetes