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The ROS cause the mitochondria to swell and disrupt their internal folded membranes, known as cristae, which house the electron transport chain
doi: 10.3748/wjg.v22.i1.361 60 MannE
Innovative clinical trial designs, including basket, umbrella, platform, and adaptive trials, may accelerate the evaluation of personalized treatment strategies while accommodating the biological complexity of resistance evolution
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