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MOTS-c works through mitochondrial and AMPK signaling rather than appetite pathways
That is the reality for a surprising number of researchers
Thus, incubating human and rodent islets under high glucose conditions results in increased expression of PC1/3 and increased secretion of GLP-1 (101, 108110), while exposure of -cells to the proinflammatory cytokine, interleukin-6, also increased GLP-1 secretion (112)
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